DNA Damage and the Gut Microbiome: From Mechanisms to Disease Outcomes

Both the number of cells and collective genome gut microbiota outnumber their mammalian hosts, metabolic physiological interactions with host have not yet been fully characterized. Cancer remains one leading causes death, more research into critical events that can lead to cancer importance be determined. The release microbial molecules simulate endogenous processes, such as inflammatory responses, or alter metabolism ingested substances. these reactions beneficial deleterious host, some genotoxic, thus contributing progression. This review focused on molecular evidence currently available mechanistic understanding how are involved in human carcinogenesis. We first reviewed key carcinogenesis, especially DNA damage proceeds tumor formulation. Then, current knowledge attributed was summarized, followed by genotoxic processes induce. Finally, we touched base association between specific dysbiosis different types concluded up-to-date well future direction for advancing our relationship development.